Hydroxychloroquine therapy for women with both recurrent pregnancy loss and autoimmune disease: association with pregnancy outcomes and maternal-fetal complications.

ABSTRACT:

Objective

To evaluate the impact of hydroxychloroquine (HCQ) on pregnancy outcomes and maternal and fetal complications in women with a history of recurrent pregnancy loss (RPL) and autoimmune disease.

Methods

The medical records of pregnant women with a history of RPL and autoimmune disease attending the Shanghai First Maternity and Infant Hospital between January 2017 and December 2019 were retrospectively reviewed. Primary outcomes were gestational week at delivery (term: ≥ 37 weeks; preterm: < 37 weeks). Secondary outcomes were mid-to-late pregnancy loss and maternal and fetal complications, defined in accordance with national and international guidelines.

Results

103 (20.9%) patients were exposed to HCQ (0.1g twice daily), 389 (79.1%) were not. There were 436 ful

SUBMITTER: Du M 

PROVIDER: S-EPMC12929442 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature