Estrogen Stabilizes Interferon-Inducible Genes During Skeletal Muscle Regeneration.

ABSTRACT: Background: Inflammation is essential for skeletal muscle repair following acute injury, and successful muscle regeneration requires a balance between pro- and anti-inflammatory signaling. Estrogen regulates inflammatory responses, suggesting a role in tissue repair. CD169+ macrophages are also associated with tissue repair. However, these cells and related interferon-inducible genes have not been investigated in regenerating muscle. Objective: To examine how 17β-estradiol treatment influences the expression and co-expression network of Siglec1 (encoding CD169), an interferon-inducible gene, during muscle regeneration. Methods: Ovariectomized mice received either 17β-estradiol or placebo before undergoing a standardized crush injury to hindlimb muscle groups and exposu

SUBMITTER: Movaghar T 

PROVIDER: S-EPMC12929644 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature