Patterns of chronic ethanol drinking in male and female cynomolgus monkeys.

ABSTRACT:

Background

Clinical and preclinical alcohol use disorder (AUD) research demonstrates that males and females differ in motivations behind drinking, patterns of drinking behaviors, and alcohol-related physiological responses and health consequences. Nonhuman primate (NHP) models of AUD have the potential to enhance our understanding of such sex differences. In NHP models, schedule-induced polydipsia is a common method to initiate ethanol drinking. In males, characteristics of drinking during the final stage of induction, when monkeys consume 1.5 g/kg/day, predict subsequent drinking patterns when monkeys have unlimited access to ethanol. The present study assessed sex differences in those predictive behaviors during induction and characterized patterns and intakes during 6 months of

SUBMITTER: Prete JN 

PROVIDER: S-EPMC12929704 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature