Metabolomic and transcriptomic analyses identify metabolic alterations and immune suppression in ovarian cancer.

ABSTRACT: Reprogramming of cellular metabolism is a hallmark of cancer, particularly ovarian cancer (OC), that contributes to rapid cancer growth and survival. However, studies using clinical specimens are limited. To identify metabolic alterations specific to OC, we performed metabolomic analysis of OC and benign ovarian tumors. The relationship between metabolomics and transcriptomics was investigated by transcriptome analysis. Fifty-one patients with OC and three with benign ovarian tumors, diagnosed between 2011 and 2014 using available frozen tissue and plasma specimens, were enrolled at the National Cancer Center Hospital. To identify metabolic alterations, plasma samples from 51 patients with OC and three with benign tumors, along with both cancerous and non-cancerous tissue samples from 44 o

SUBMITTER: Yamaguchi M 

PROVIDER: S-EPMC12929718 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature