Effects of human embryonic stem cell-derived Schwann cells for nerve regeneration after facial nerve injury.

ABSTRACT: Facial nerve transection frequently results in incomplete functional recovery despite microsurgical repair due to axonal misalignment and limited intrinsic regenerative capacity. Schwann cells (SCs) are essential for peripheral nerve repair, supporting axon elongation, remyelination, and neurotrophic signaling. Human embryonic stem cell-derived Schwann cells (hESC-SCs), including Schwann cell precursors (SCPs) and immature SCs, constitute a scalable source of cells for tissue-engineered nerve grafts. This study investigated whether silicone conduits loaded with hESC-SCs could enhance facial nerve regeneration following complete transection in rats. hESCs were differentiated into SCPs or immature SCs using a stepwise in vitro protocol and purified by fluorescence-activated cell sorti

SUBMITTER: Yoo MC 

PROVIDER: S-EPMC12929842 | biostudies-literature | 2026 Jan-Dec

REPOSITORIES: biostudies-literature