Piperazine-grafted magnetic graphene oxide as a sustainable heterogeneous catalyst for solvent-free Biginelli reaction.

ABSTRACT: Multi-component reactions (MCRs) are powerful tools for the one-pot synthesis of complex organic compounds, with the Biginelli reaction being one of the most important due to its versatility in synthesizing a wide range of dihydropyrimidine-2-ones (DHPMs) with diverse biological activities. However, traditional MCR catalysts are often homogeneous and challenging to recycle, leading to environmental concerns and high costs. In this study, we developed a novel heterogeneous catalyst for the Biginelli reaction by functionalizing graphene oxide (GO) with piperazine (NH) to form a Fe₃O₄@GO-NH nanocomposite. The catalyst was characterized using FT-IR, TGA, and SEM/EDX and showed high catalytic activity for the Biginelli reaction under solvent-free conditions. The optimal re

SUBMITTER: Rezaei-Seresht E 

PROVIDER: S-EPMC12930250 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature