Salivary Sialic Acid Levels as a Biomarker for Early Detection of Oral Precancer and Oral Cancer: Systematic Review and Meta-Analysis.

ABSTRACT:

Objective

Salivary sialic acid (SSA) has been detected as biomarker in several cancers and the level of salivary sialic acids has been proven to have a potential diagnostic value in early detection of cancer.  This systematic review aims to assess Salivary Sialic Acid (SSA) levels as a biomarker for early detection of oral precancer and oral cancer.

Data sources

A comprehensive Literature search was conducted in various databases such as PubMed, Scopus, Google scholar and ProQuest. Quality assessment of articles was done by Newcastle Ottawa Quality Assessment Scale.

Results

A total of 22 studies were included in the systematic review and 14 articles were included for meta-analysis. Studies showed an increase in SSA levels in both oral precancer (SMD 1.79; 95% CI 0.41-

SUBMITTER: Jayasankar P 

PROVIDER: S-EPMC12930304 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature