Disrupted Tryptophan Metabolism Mediates Manganese-Induced Neurogenesis and Neuroinflammatory Impairments: Rescue by Exogenous Melatonin.

ABSTRACT: Manganese (Mn) is a common environmental pollutant, and excessive exposure can lead to motor dysfunction resembling Parkinson's disease. Increasing evidence suggests that Mn impairs endogenous neurogenesis and hinders neural repair. This study aims to investigate the effects of both acute and long-term Mn exposure on neurogenesis and to elucidate the underlying mechanisms. By establishing acute (7 and 14 days) and long-term (2 and 4 months) Mn exposure mouse models, we assessed neurogenesis under different exposure conditions. The mRNA sequencing, untargeted metabolomics, and metagenomics were employed to uncover the molecular pathways involved in Mn-induced neurogenesis impairment. The results revealed that early stage Mn exposure, including acute and 2 months exposure, transiently promot

SUBMITTER: Wang X 

PROVIDER: S-EPMC12930312 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature