Type 1 and CD103⁺ Type 2 Conventional Dendritic Cells Are Decreased in Active Patients with Ulcerative Colitis but Not with Crohn's Disease.

ABSTRACT: This study aimed to characterize human intestinal conventional dendritic cells (cDCs) in health and inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD). Three cDC subsets (CD103^- cDC2, CD103⁺ cDC2, and cDC1) were identified from lamina propria mononuclear cells. Their phenotype and function were analyzed in healthy and IBD-inflamed gut tissues. In the healthy gut, cDC2 predominated over cDC1, with CD103⁺ cDC2 dominating the duodenum and CD103^- cDC2 prevalent in the ileum and colon. CD103⁺ cDC2 expressed higher PD-L1 and produced more IL-10. In culture, CD103⁺ cDC2 increased proportionally unless inhibited by LPS. All subsets induced IL-10⁺ helper T-cell differentiation, wit

SUBMITTER: Arribas-Rodriguez E 

PROVIDER: S-EPMC12930326 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature