Novel and sustainable microfabricated Cu ion selective sensor doped with ionophore and supported with docking study for determination of vonoprazan fumarate in tablet dosage form.

ABSTRACT: In the field of drug analysis, there is a growing emphasis on developing techniques that are environmentally friendly, cost-effective, and efficient. To align with the principles of green analytical chemistry and to support the advancement of portable and handheld devices, an innovative microfabricated ion selective electrode (ISE) has been developed for the detection of Vonoprazan fumarate (VON). The development of this electrode involved a two-step optimization process. Initially, a range of ionophores were screened to determine the one with the highest selectivity for VON. Through molecular docking studies, gamma-cyclodextrin (γ-cyclodextrin) was identified as demonstrating maximal activity towards VON. The second optimization step involved incorporating a graphene nanocomposite as an i

SUBMITTER: Zaher H 

PROVIDER: S-EPMC12930549 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature