On-scene selective brain cooling in ventricular fibrillation cardiac arrest: pilot results from the PRINCESS2 randomised trial.

ABSTRACT:

Background

Although ischemia-reperfusion brain injury represents a major clinical problem after cardiac arrest, no neuroprotective treatment currently exists. The PRINCESS2 trial is designed to confirm previous findings, indicating that on-scene selective brain cooling using a portable trans-nasal cooling method improves complete neurological recovery after out-of-hospital cardiac arrest (OHCA) with initial shockable rhythms (e.g. ventricular fibrillation). This prespecified pilot phase aimed to assess protocol adherence and safety aspects for this early cooling strategy.

Methods

The prespecified pilot phase includes the first 100 patients in the main PRINCESS2 trial, an ongoing European multicentre trial enrolling 1,022 OHCA patients with initial shockable rhythm. Patients

SUBMITTER: Dillenbeck E 

PROVIDER: S-EPMC12930594 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature