Sex differences in the relationship of biomarker change to memory decline in early Alzheimer's disease: an observational cohort study.

ABSTRACT:

Background

Alzheimer's disease (AD) exhibits sex differences in pathology and cognitive trajectories. Understanding how these differences manifest across the Alzheimer's continuum can improve early detection, diagnostics, and interventions. We examined sex differences in the association between cerebrospinal fluid (CSF) pTau181/Aβ42 ratio changes and verbal memory decline across the preclinical and mild cognitive impairment (MCI) stages of AD.

Methods

In this retrospective, longitudinal, observational study, data were extracted from 401 participants (age range: 55-87.8, 98% non-Hispanic White) of the Alzheimer's Disease Neuroimaging Initiative cohort study who were classified as either preclinical AD (78 females, 73 males) or MCI (104 females, 146 males) at baseline and had

SUBMITTER: Sundermann EE 

PROVIDER: S-EPMC12930658 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature