Dataset Information
TRPV2 regulates cell fate in the human granulosa-like tumor cell line KGN: implications for granulosa cell tumors and cannabidiol.
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ABSTRACT:
SUBMITTER: Eubler K
PROVIDER: S-EPMC12930786 | biostudies-literature | 2026 Feb
REPOSITORIES: biostudies-literature
Publications
TRPV2 regulates cell fate in the human granulosa-like tumor cell line KGN: implications for granulosa cell tumors and cannabidiol.
Cell communication and signaling : CCS 20260212 1
BACKGROUND: The transient receptor potential vanilloid 2 (TRPV2) channel is known to have strong species-dependent activation modes and divers functions. Based on previous results, which showed expression by human ovarian granulosa cells, we studied human TRPV2 in human granulosa cell tumors (GCTs) and derived cells (KGN cells). GCTs are rare ovarian tumors, for which neither specific therapies, nor adequate markers are available. METHODS: We analyzed primary GCTs, including a panel of 63 GCT sa ...[more]
