Real-world validation of the SLERPI diagnostic model with concordance and discordance analysis across established SLE classification criteria.

ABSTRACT:

Objective

Systemic lupus erythematosus (SLE) is a clinically heterogeneous disease in which early and atypical presentations frequently challenge existing classification frameworks. The Systemic Lupus Erythematosus Risk Probability Index (SLERPI) was developed as a probabilistic diagnostic aid, but its real-world performance relative to established classification criteria across disease phenotypes remains incompletely characterized.

Methods

In this multicenter, cross-sectional study, we evaluated 1,281 participants, including 655 expert-confirmed SLE patients and 626 controls with other rheumatic diseases. Diagnostic performance of SLERPI, ACR-1997, SLICC-2012, and EULAR/ACR-2019 criteria was assessed against expert clinical diagnosis as the reference standard. Subgroup anal

SUBMITTER: El-Farra OA 

PROVIDER: S-EPMC12930877 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature