Dataset Information
SS-31 improves the quality of maternally aged oocytes by ameliorating mitochondrial function and metabolism.
Ontology highlight
ABSTRACT:
SUBMITTER: Xiong D
PROVIDER: S-EPMC12930897 | biostudies-literature | 2026 Jan
REPOSITORIES: biostudies-literature
Publications
SS-31 improves the quality of maternally aged oocytes by ameliorating mitochondrial function and metabolism.
Journal of ovarian research 20260129 1
Reproductive aging is closely associated with poor oocyte quality in vitro maturation, but effective approaches to ameliorate it have still not been fully determined. Here, we found that SS-31 supplementation efficaciously improved oocyte maturation and early embryonic development from aged mice. Specifically, SS-31 remarkably restored the normal spindle/chromosome structure, fertilization ability, mitochondrial distribution, ΔΨm and mitophagy in aged oocytes. In contrast, SS-31 reduced oocyte a ...[more]
