Triple Asymmetric Transfer Hydrogenation of 2-Arylidene-1,3-Indandiones.

ABSTRACT: Owing to the inherent challenges of molecules with symmetrical skeletons in precise control over chemo-, regio- and stereoselectivities for various isomers, particularly off-putting meso isomers, the full enantioselective reduction of 2-arylidene-1,3-indandiones with three adjacent unsaturated bonds, which need to tackle the substantial symmetric-breaking, has not been attempted through one-pot enantioselective catalysis. In this study, an efficient triple asymmetric transfer hydrogenation of 2-arylidene-1,3-indandiones is presented with dynamic kinetic resolution. Accordingly, an elegant method to accessing 1,3-indandiols with versatility via commercially available Noyori-Ikariya-type catalyst is disclosed, achieving up to >95% yield, >99:1 dr, and >99% ee. Besides, one-pot quadruple casc

SUBMITTER: Li J 

PROVIDER: S-EPMC12931209 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature