P24 family proteins are critical for cell wall integrity, protein secretion, and virulence in <i>Candida albicans</i>.

ABSTRACT: Candida albicans is a fungal commensal and also a prevalent pathogen of humans. p24 proteins are a family of type I membrane proteins regarded as cargo receptors for endoplasmic reticulum (ER) to Golgi transport and are thought to be involved in regulating secretion. Here, we sought to explore the impact of this family of proteins on C. albicans pathogenicity. The expression of all four members of the p24 family is upregulated during invasive candidiasis. Their expression is independent of yeast-to-hypha transition but is highly induced by tissue culture conditions. We then generated single deletion mutants for each member of the p24 family for phenotypic characterization. All these mutants exhibit significantly attenuated virulence in a mouse model of systemic infection and

SUBMITTER: Yu X 

PROVIDER: S-EPMC12931272 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature