Association between circulating irisin level and depression: a systematic review and meta-analysis.

ABSTRACT:

Background

Previous studies have presented controversial results about the association between irisin and depression. This research is designed to explore the circulating irisin levels in depressive patients.

Methods

From the earliest available records up to 18 July 2024, searches were conducted in databases of PubMed, Embase, Web of Science, the Cochrane Library, and Scopus, in order to identify the relevant articles assessing the correlation between irisin and depression in humans. Two reviewers screened reports, retrieved and collected data independently.

Results

Totally, eight articles with 2044 samples (733 depressive patients and 1311 non-depressive individuals) were involved. The results indicated lower circulating irisin levels in depression (standardized mean

SUBMITTER: Han C 

PROVIDER: S-EPMC12931329 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature