Prognostic value of C-reactive protein in patients with melanoma: a meta-analysis.

ABSTRACT:

Background

C-reactive protein (CRP) has been widely investigated for its prognostic value for melanoma, however, findings remained different. Consequently, this meta-analysis was performed for identifying its precise role in forecasting melanoma prognosis.

Methods

We searched PubMed, Web of Science, Embase and Cochrane Library till 25 January 2025, and computed combined hazard ratios (HRs) and 95% confidence intervals (CIs) for estimating CRP's effect on forecasting overall survival (OS) and progression-free survival (PFS) of melanoma.

Results

Nineteen studies consisting of 4634 cases were enrolled into the present work. As suggested by our data, higher CRP showed remarkable relation to dismal OS (HR = 2.26, 95% CI = 1.89-2.71, p < 0.001) and inferior PFS (HR =

SUBMITTER: Xing X 

PROVIDER: S-EPMC12931336 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature