Sex Differences in Amyloid Pathology by Race, Ancestry, and Apolipoprotein E ε4 in an Admixed Autopsy Sample.

ABSTRACT:

Importance

Sex and racial or ancestral disparities in Alzheimer disease remain incompletely understood; autopsy studies that examine amyloid, tau, and genetic factors are scarce.

Objective

To test whether neuritic plaque burden and cognitive outcomes differ by sex and whether sex modifies the effects of apolipoprotein E ε4 (APOEε4), informant-reported race, and African ancestry.

Design, setting, and participants

This was a cross-sectional study using postmortem neuropathological data from the Biobank for Aging Studies, University of São Paulo, São Paulo, Brazil. A total of 2268 autopsies from a population-based, diverse clinicopathological sample were collected between April 2004 and March 2025.

Exposures

Sex, informant-reported race (Black, White), African anc

SUBMITTER: Abu Raya M 

PROVIDER: S-EPMC12931469 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature