Disruption of Hepatic Insulin Signaling Causes Phospholipid Dysregulation in Mice.

ABSTRACT: Phospholipids are important components of the bilayer of biological membranes. Alterations of phospholipids are associated with metabolic disorders, including insulin resistance. However, how impaired insulin signaling impacts phospholipids has not been well established. Disruption of hepatic insulin signaling is achieved by insulin receptor substrate 1 (IRS1) and IRS2 double deletion (DKO) in the liver. Further deletion of TGF-β1 or Foxo1 in the liver of DKO mice was used to examine the role of TGF-β1 or Foxo1 in contributing to the alterations of phospholipid metabolism in DKO mice. Disruption of hepatic insulin signaling led to the dysregulation of phospholipids, including phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylinositol (PI), phosphatidylserine (PS), sphing

SUBMITTER: Pan Q 

PROVIDER: S-EPMC12931579 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature