Risk in Women Emerges at Lower Coronary Plaque Burden Than in Men: PROMISE Trial.

ABSTRACT:

Background

Quantitative coronary plaque measures differ in prognostic value between women and men. It remains unclear whether cardiovascular risk increases proportionally with plaque extent in both sexes. We aimed to compare cardiovascular risk trajectories across quantitative coronary plaque measures in women and men with stable chest pain.

Methods

We analyzed data from the PROMISE (Prospective Multicenter Imaging Study for Evaluation of Chest Pain) coronary computed tomography angiography arm, quantifying total coronary plaque volume and burden (plaque burden [PB]; % vessel volume), including calcified, noncalcified, and low-attenuation components. Associations with major adverse cardiovascular events (death, myocardial infarction, or unstable angina hospitalization) were

SUBMITTER: Brendel JM 

PROVIDER: S-EPMC12931657 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature