Substance use and menopausal hormone therapy: Treatment initiation and interruption among US women with and without HIV, 2008-2019.

ABSTRACT:

Objective

This study compares rates of menopausal hormone therapy (MHT) initiation between perimenopausal and postmenopausal women with moderate-severe vasomotor symptoms (VMS) with and without substance use in a longitudinal cohort of diverse US women with or without HIV.

Methods

Using menopause symptoms, hormone use, and substance use data from Women's Interagency HIV Study biannual visits (10/2008-9/2019), we compared initiation of and breaks in MHT among participants with moderate-severe VMS (1) with or without current substance use and (2) with or without ever using substances. We calculated unadjusted rates and adjusted rate ratios (RR) for demographics and health variables using Poisson regression.

Results

The median age of participants (n = 1579) with moderate

SUBMITTER: Knittel AK 

PROVIDER: S-EPMC12931683 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature