Gut dysbiosis impacts estrogen levels in APP/PS1 transgenic female mice.

ABSTRACT: Alzheimer's disease (AD) is the most common form of dementia, with a higher prevalence in women than in men. It has been suggested that the decline in estrogen production after menopause may increase the risk of developing dementia. Additionally, patients with AD often display dysbiosis of the gut microbiota (GM), even in the early stages of the disease. The GM plays a crucial role in modulating systemic estrogen levels through a mechanism known as the estrobolome. However, it remains unclear whether gut dysbiosis contributes to estrogen imbalance and subsequent cognitive decline in women. In this study, we aim to investigate whether alterations in the GM impact estrogen availability and cognitive function in 6-month-old female APP/PS1 (TG) mice compared to age-matched wild-type (WT

SUBMITTER: Romero-Flores IS 

PROVIDER: S-EPMC12931724 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature