Leucine Zipper-based Cell Sorting for Purification of Dual-vector-transduced Cells.

ABSTRACT: Adoptive T cell therapies, including chimeric antigen receptor (CAR) T cells, have demonstrated impressive clinical activity against hematologic malignancies and are showing promise in treating solid tumor malignancies. Despite these successes, multiple mechanisms of resistance to T cell immunotherapy have been identified that limit therapeutic success, including loss of or weak expression of target antigens, development of T cell exhaustion, and the presence of an immunosuppressive tumor microenvironment. Multiple cell engineering strategies have been developed to overcome these mechanisms of resistance. However, multiple mechanisms of resistance can occur simultaneously, necessitating a combination of multiple engineering strategies to optimize anti-tumor activity. Vector packaging const

SUBMITTER: Su K 

PROVIDER: S-EPMC12931735 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature