High burden and genetic diversity of β-lactamase-producing Escherichia coli and Klebsiella pneumoniae causing community-acquired urinary tract infections in Southeastern Gabon.

ABSTRACT:

Background

The increasing prevalence of β-lactamase-producing Escherichia coli and Klebsiella pneumoniae in community-acquired urinary tract infections (CA-UTIs) represents a growing public health challenge in low-resource settings. Data from Central Africa remain limited. This study investigated antimicrobial resistance profiles and phylogenetic diversity of these pathogens in southeastern Gabon.

Methods

Patients presenting with CA-UTIs were screened, and isolates of E. coli and K. pneumoniae were collected. Antimicrobial susceptibility testing was performed using the Kirby-Bauer disk diffusion method and interpreted according to EUCAST 2024 guidelines. Phenotypic screening identified extended-spectrum β-lactamase (ESBL), AmpC, and carbapenemase production. Polymerase chain

SUBMITTER: Mouanga-Ndzime Y 

PROVIDER: S-EPMC12931754 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature