Unexpected diversification of DENV2 genotype III in Colombia: New Insights and application of the globalized nomenclature.

ABSTRACT: Dengue is the most prevalent mosquito-borne viral disease worldwide and constitutes a major public health concern in Colombia. The disease is caused by four antigenically distinct dengue virus serotypes (DENV-1 to DENV-4), which share more than 65% genome identity. Although all four serotypes co-circulate in Colombia, secondary infections with DENV-2 have frequently been associated with more severe clinical outcomes. DENV-2 comprises six genotypes, of which genotype III has been the dominant lineage in the Americas over the past two decades. In this study, we investigated the evolutionary dynamics of DENV-2 genotype III in Colombia by analyzing available whole-genome coding sequences together with twenty-six newly generated genomes. Bayesian and maximum-likelihood phylogenetic approaches w

SUBMITTER: Calvo EP 

PROVIDER: S-EPMC12931762 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature