Death by Neurologic Criteria in Neonates Undergoing Extracorporeal Membrane Oxygenation: Extracorporeal Life Support Organization Registry Study, 2010-2023.

ABSTRACT:

Objectives

To identify factors associated with the development of death by neurologic criteria (DNC) in neonates treated with extracorporeal membrane oxygenation (ECMO).

Design

Retrospective registry study.

Setting

Data reported to the Extracorporeal Life Support Organization registry from 2010 to 2023.

Patients

Neonates (≤ 28 d old) who were supported with ECMO, excluding those born before 37 weeks' gestation or with missing gestational age data. The final cohort comprised 14,970 neonates.

Interventions

None.

Measurements and main results

DNC occurred in 70 neonates in the cohort (0.5%), accounting for 2% of overall mortality rate. Pre-ECMO factors associated with greater relative risk ratio (RRR) of DNC included pre-ECMO cardiac arrest (RRR, 2.6

SUBMITTER: Polito A 

PROVIDER: S-EPMC12931849 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature