Effects of anatomy and head motion on spatial patterns of deformation in the human brain.

ABSTRACT:

Purpose

To determine how the biomechanical vulnerability of the human brain is affected by features of individual anatomy and loading.

Methods

To identify the features that contribute most to brain vulnerability, we imparted mild harmonic acceleration to the head and measured the resulting brain motion and deformation using magnetic resonance elastography (MRE). Oscillatory motion was imparted to the heads of adult participants using a lateral actuator (n = 24) or occipital actuator (n = 24) at 20 Hz, 30 Hz, and 50 Hz. Displacement vector fields and strain tensor fields in the brain were obtained from MRE measurements. Anatomical images, as well as displacement and strain fields from each participant were rigidly and deformably aligned to a common atlas (MNI-152). Vulnerabil

SUBMITTER: Escarcega JD 

PROVIDER: S-EPMC12931853 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature