Whole-Body Knockout of the AhR (Aryl Hydrocarbon Receptor) Ameliorates Atherosclerosis Due to Altered Lipid Metabolism.

ABSTRACT:

Background

Atherosclerotic cardiovascular disease, characterized by an imbalanced lipid metabolism and a dysregulated immune response, is a major cause of death worldwide. The AhR (aryl hydrocarbon receptor) is a ligand-activated transcription factor that is highly expressed in the liver and primarily known for its role in detoxification. However, recent studies suggest that the AhR also plays a key role in immune regulation, indicating that this receptor can influence the development of atherosclerosis.

Methods

Apoe-/- and Apoe-/-Ahr-/- mice were fed a western-type diet for 12 weeks to induce atherosclerosis. Aortic roots were analyzed for size and composition of atherosclerotic plaques. Plasma samples were characterized for inflammation and lipid levels. Liver samples were

SUBMITTER: Huchzermeier R 

PROVIDER: S-EPMC12931860 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature