Hyperadrenergic postural tachycardia syndrome associated with augmented neurovascular transduction.

ABSTRACT:

Purpose

Muscle sympathetic nerve activity (MSNA) is valuable for managing postural tachycardia syndrome (POTS), but microneurography is clinically impractical. We investigated whether the Valsalva phase 2 diastolic blood pressure rise (DBP_{VM2l_rise}) serves as a sympathetic marker and proposed enhanced neurovascular transduction as a pathophysiological mechanism in hyperadrenergic POTS.

Methods

We included 21 POTS women and 22 healthy women to perform Valsalva and microneurography. MSNA spike rate was obtained using stationary wavelet transformation. The DBP_{VM2l_rise} cut point for hyperadrenergic POTS was optimized by the golden section search with its correlation to phase 2 MSNA spike rate as an objective function. We defined peripheral sympathetic neur

SUBMITTER: Kulapatana S 

PROVIDER: S-EPMC12931957 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature