Dosing and Route of Steroid Induction Therapy in Non-Severe Autoimmune Hepatitis Do Not Affect Time to Biochemical Response.

ABSTRACT:

Background and aims

Optimal steroid induction therapy in autoimmune hepatitis (AIH) is unclear. We aimed to investigate the relationship between steroid dosing, route of administration, and time to biochemical response to help standardize AIH practice patterns and reduce excess steroid exposure.

Methods

We conducted a retrospective cohort study of adult patients with non-severe AIH receiving induction steroid therapy. Patients were stratified into three treatment groups: (1) low-dose oral steroids (n = 39; prednisone < 40 mg/day or budesonide 9 mg/day), (2) high-dose oral steroids (n = 32; prednisone 40 mg/day), and (3) intravenous steroids (n = 21; methylprednisolone 1 g/day). Time to biochemical response and predictors of biochemical response were comp

SUBMITTER: Lavette LE 

PROVIDER: S-EPMC12932122 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature