Association between hypothyroidism and risk of chronic kidney disease: evidence from a systematic review and meta-analysis.

ABSTRACT:

Background

Chronic kidney disease (CKD) has become a significant issue in global public health, with its prevalence showing a persistent upward trend. Traditional risk factors cannot fully explain the persistent increase in incidence rates. Hypothyroidism, a common endocrine disorder, is considered a potential non-traditional risk factor for CKD, but the evidence remains inconsistent. This study aims to systematically evaluate the association between hypothyroidism and CKD risk.

Methods

Search PubMed, Embase, Web of Science, and Cochrane Library databases for relevant literature up to September 1, 2025. Included observational studies reporting the association between overt or subclinical hypothyroidism and CKD risk, providing odds ratios (OR) or hazard ratios (HR) with 95% c

SUBMITTER: Zhuang WK 

PROVIDER: S-EPMC12932160 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature