Association between the serum uric acid to HDL cholesterol ratio and forearm bone mineral density in middle-aged and older adults.

ABSTRACT:

Background

Osteoporosis has emerged as a growing public health concern due to its high prevalence and substantial economic burden on both individuals and society. Recent studies have identified the serum uric acid to high-density lipoprotein cholesterol ratio (UHR) as a novel predictive biomarker for various diseases. However, its association with bone mineral density (BMD) remains unclear.

Objective

This study evaluated the association of the UHR and forearm BMD (FR-BMD) in a middle-aged and elderly cohort. We also assessed the interaction effects of age, sex, and body mass index (BMI).

Methods

A total of 4,958 adults aged ≥50 years were enrolled from health examinees at Heze Municipal Hospital (2022-2025). We collected demographic data, serum lipids, and uric acid l

SUBMITTER: Song F 

PROVIDER: S-EPMC12932171 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature