Polyphenol-rich Chinese olive extracts attenuate lipid accumulation in HepG2 cells, accompanied by AMPK phosphorylation and miRNA alterations.

ABSTRACT:

Introduction

Chinese olive (Canarium album L.) is a rich source of phenolic compounds and has been suggested to exhibit distinct lipid-lowering bioactivities from those reported for Mediterranean olive polyphenols.

Methods

This study investigated the effects of polyphenol-rich Chinese olive extracts on sodium oleate-induced lipid accumulation in HepG2 cells.

Results

Treatment with extracts was associated with a significant reduction in intracellular total lipid and triglyceride levels in a concentration-dependent manner. RT-qPCR results revealed that extract treatment was accompanied by the downregulation of lipogenesis-related genes (SREBP-1c, ACC1, FASN, and DGAT2) and the upregulation of β-oxidation-associated genes (PGC-1α, PPARα, CPT-1A, and ACOX1).

SUBMITTER: Wang H 

PROVIDER: S-EPMC12932180 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature