Integrated multi-omics and phenotypic validations reveal biocontrol mechanisms of <i>Bacillus velezensis</i> XM18-5 against potato common scab.

ABSTRACT: Potato common scab, caused by pathogenic Streptomyces species, is a devastating soil-borne disease that severely compromises potato yield and marketability. To develop effective biological control strategies and elucidate their molecular mechanisms, this study isolated a potent antagonistic strain, XM18-5, from disease-suppressive soil. Through a systematic approach integrating phenotypic assays, whole-genome sequencing, and non-targeted metabolomics, the strain was identified as Bacillus velezensis. In vitro assays demonstrated that XM18-5 exhibits significant antagonistic activity against Streptomyces scabies X-1 (60.72% inhibition rate), causing severe hyphal deformation and lysis as revealed by scanning electron microscopy. In pot experiments, XM18-5 treatment achi

SUBMITTER: Wang X 

PROVIDER: S-EPMC12932232 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature