Sex-specific association between osteoporosis and cataracts: UK Biobank and Hong Kong Osteoporosis Study.

ABSTRACT: In two large, ethnically different prospective cohorts from the UK and Hong Kong, osteoporosis was associated with a higher risk of age-related cataracts, particularly in women. Proteomic mediation analysis identified five circulating proteins (MEPE, GDF15, TCN2, CDCP1, SIGLEC1) that may link osteoporosis to cataract development, warranting future mechanistic investigation.

Purpose

Osteoporosis and cataracts are frequently comorbid age-related conditions. This study aims to investigate the association between osteoporosis and the risk of age-related cataracts in cohorts from the United Kingdom (UK) and Hong Kong.

Methods

Prospective cohort studies were conducted in participants aged ≥ 40 years without cataracts at baseline, using data from the UK Biobank (UKB; n = 337,952) an

SUBMITTER: Zhang X 

PROVIDER: S-EPMC12932269 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature