Rim enhancement on imaging of pancreatic ductal adenocarcinoma: systematic review and meta-analysis of biological and prognostic values.

ABSTRACT: Pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive malignancies, with limited therapeutic options and poor prognosis. Dynamic contrast-enhanced imaging provides valuable non-invasive information on tumor biology, and rim enhancement (RE) on computed tomography (CT) or magnetic resonance imaging (MRI) has emerged as a potential biomarker of aggressive disease. To clarify its clinical significance, a systematic review and meta-analysis of studies published up to May 31st, 2025, in Medline, Scopus, Web of Science, and the Cochrane Library was conducted. Twelve studies (10 retrospective, 2 prospective) including 2207 patients were analyzed. The pooled prevalence of RE was 36.3%, with a good inter-observer agreement (κ = 0.808). RE was consistently associated with reduce

SUBMITTER: Renzulli M 

PROVIDER: S-EPMC12932284 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature