Efficacy and safety of telitacicept combined with immunosuppressive therapy for IgA nephropathy: a retrospective multicenter cohort study.

ABSTRACT:

Background

To investigate the efficacy and safety of telitacicept combined with glucocorticoid/mycophenolate mofetil (GM) versus telitacicept in the treatment of immunoglobulin A nephropathy (IgAN).

Methods

This retrospective, multicenter cohort study enrolled patients aged ≥ 18 years with biopsy-proven IgAN who were treated with telitacicept. All participants had a baseline eGFR ≥ 30 mL/min/1.73 m² and proteinuria excretion ≥ 0.75 g/day after receiving at least 1 month of optimized supportive treatment. Clinical data were collected over 9 months.

Results

A total of 256 patients were enrolled in the study, with 125 patients receiving telitacicept monotherapy and 131 patients receiving telitacicept plus GM therapy. The mean age was 39.5 ± 11.6 years, and 100 patients (

SUBMITTER: Zeng F 

PROVIDER: S-EPMC12932424 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature