Association of leuko-glycemic index with mortality in critically ill stroke patients: analysis from the MIMIC-IV database and an institutional cohort.

ABSTRACT:

Background

The leuko-glycemic index (LGI), combining white blood cell count and blood glucose, reflects systemic inflammation and stress hyperglycemia. Its prognostic value in critically ill stroke patients remains unclear. This study evaluated the association between LGI and mortality using the MIMIC-IV database and an independent institutional cohort.

Methods

Patients with acute stroke were identified from MIMIC-IV (version 3.1) and a neurosurgical intensive care unit cohort. LGI was calculated as white blood cell count (×10⁹/L) × blood glucose (mg/dL)/1,000 using measurements within the first 24 h after ICU admission and categorized into quartiles. The primary outcome was 28-day mortality. Secondary outcomes included in-hospital mortality in both cohorts and 36

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12932427 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature