Plant polysaccharides in neuroprotection: mechanistic insights across central nervous system disorders.

ABSTRACT: Central nervous system (CNS) disorders pose a major global health burden, and the limited efficacy and adverse effects of current pharmacotherapies underscore the need for more effective therapeutic strategies. Plant polysaccharides, as key bioactive metabolites of medicinal plants, have attracted increasing attention due to their broad biological activities and favorable safety profiles. In this review, we comprehensively summarize recent advances in understanding their neuroprotective effects, emphasizing mechanistic pathways that include the suppression of neuroinflammation, mitigation of oxidative stress, inhibition of neuronal apoptosis, modulation of autophagy, and maintenance of gut microbiota homeostasis. These mechanisms are examined across diverse preclinical models, with particu

SUBMITTER: Yu Q 

PROVIDER: S-EPMC12932451 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature