Novel non-antibiotic triple therapy for <i>Helicobacter pylori</i>-positive functional dyspepsia patients resistant to conventional antibiotic treatments: an exploratory pilot study.

ABSTRACT:

Purpose

The rising antibiotic resistance has significantly reduced the efficacy of standard bismuth-based quadruple therapy for Helicobacter pylori (H. pylori) infections, particularly in patients with multiple eradication failures. This study evaluates a novel non-antibiotic triple therapy comprising Weisu granules, berberine hydrochloride, and Bio-Three-a probiotic formulation containing Clostridium butyricum TO-A, Enterococcus faecalis T-110, and Bacillus mesentericus TO-A-in treating H. pylori-positive functional dyspepsia (FD) patients resistant to conventional antibiotic treatments.

Patients and methods

A two-center retrospective analysis involved 48 FD patients who had previously failed at least two H. pylori eradicatio

SUBMITTER: Zhan C 

PROVIDER: S-EPMC12932454 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature