Episode-wide Maudsley staging in treatment-resistant depression: a longitudinal tertiary-care comparison of dimensional and categorical outcomes.

ABSTRACT:

Background

Unlike typical categorical definitions of treatment-resistant depression (TRD) based on antidepressant (AD) trial failures, the Maudsley Staging Method (MSM) is a dimensional measure of resistance also rating episode duration, baseline depression severity and failure of augmentation strategies and ECT. However, MSM has not previously been used longitudinally across the full depressive episode, from episode onset to remission. We applied episode-wide MSM (EW-MSM) in patients with Major Depressive Disorder naturalistically followed to remission in a tertiary-care setting and categorized as 1^st and 2^nd AD trial remitters, TRD remitters and TRD non-remitters (categorical outcomes). The study aimed to investigate clinicodemographic and treatment-related

SUBMITTER: Antoniou A 

PROVIDER: S-EPMC12932473 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature