Brain lipidomics for region-specific biomarker discovery in neurodegenerative diseases.

ABSTRACT:

Background

Alzheimer's disease (AD), Parkinson's disease (PD), and Huntington's disease (HD) are progressive neurodegenerative diseases (NDs) characterized by chronic neuronal loss. The lack of effective treatments highlights the urgent need for reliable lipid biomarkers to enable diagnosis and monitor disease progression. Previous lipidomic investigations of altered lipid metabolism have focused on a single disease type, limiting cross-disease comparisons.

Methods

We applied the untargeted liquid chromatography-mass spectrometry (LC/MS) technique to profile brain lipidome alterations and to identify disease-specific lipid biomarkers across AD, HD, and PD. Brain tissue samples were collected from four cerebral lobes of healthy volunteers (HV, n = 24) and patients diag

SUBMITTER: Jayaprakash J 

PROVIDER: S-EPMC12932490 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature