Locating the epileptogenic zone for drug-resistant epilepsy through neuroelectrophysiological brain network topology.

ABSTRACT:

Introduction

Drug-resistant epilepsy (DRE) constitutes approximately one-third of the epilepsy population, posing a significant challenge due to low seizure freedom rates. Accurate localization of the epileptogenic zone (EZ) is the prerequisite for successful surgery. However, the limitations of conventional visual inspection underscore an urgent need for novel localization strategies based on quantitative brain network topology.

Methods

This study established a hierarchical analytical framework to independently analyze neuroelectrophysiological signals from scalp EEG (used for macroscopic hypothesis formulation) and stereoelectroencephalography (SEEG, used for mesoscopic confirmation). We included 25 patients with favorable surgical outcomes and constructed brain networks f

SUBMITTER: Zhang W 

PROVIDER: S-EPMC12932511 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature