Integrative analysis of DNA methylation and inflammatory protein biomarkers in hypertension.

ABSTRACT:

Background and objective

To investigate the relationship between inflammation and hypertension by comparing epigenetic and serum biomarkers of inflammation and their association with target organ damage (TOD).

Methods

The epigenome-wide methylation profiles of peripheral leukocyte DNA from 176 patients with hypertension were analyzed using Illumina Infinium Methylation EPIC BeadChips. The commercially available Olink^® Target 96 Inflammation panels were utilized to evaluate markers associated with inflammation. We identified CpG-protein association protein quantitative trait methylation loci (pQTMs) using mixed linear regression, adjusting for potential confounders. The possible roles of the discovered pQTMs were ascertained by Kyoto Encyclopedia of Genes and Genom

SUBMITTER: Zhu M 

PROVIDER: S-EPMC12932573 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature