BACH1-mediated transcriptional repression of pro-angiogenic factors drives angiogenic impairment in hypertension.

ABSTRACT:

Background

Impaired angiogenesis is a well-recognized pathophysiological feature of hypertension, yet the molecular mechanisms linking elevated blood pressure to angiogenic impairment remain incompletely understood. Endothelial transcriptional regulation may play a critical role in this process.

Methods

Angiogenesis was assessed in Angiotensin II (AngII)-induced hypertensive mice and endothelial cells using in vivo and in vitro approaches. BACH1 expression and regulation were examined following AngII stimulation. Transcriptional repression by BACH1 was investigated at pro-angiogenic gene promoters. Circulating angiogenic factors were measured in hypertensive patients and analyzed in relation to blood pressure. Endothelial-enriched BACH1 knockdown was performed

SUBMITTER: Gao D 

PROVIDER: S-EPMC12932592 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature