Therapeutic drug monitoring of daptomycin in a critically ill patient cohort.

ABSTRACT:

Background

Pharmacokinetics of antimicrobial agents are altered in critically ill patients. Therefore, therapeutic drug monitoring (TDM) has gained much attention in recent years. Specifically, the role of TDM for daptomycin, its potential influence on dose adaptations and subsequent daptomycin levels, as well as daptomycin-related side effects is so far unclear in the critical care setting.

Methods

This was a retrospective study including critically ill, adult patients from January 2010 to July 2023. No criteria for TDM were predefined and the decision to perform TDM was left to the discretion of the treating physician. The primary outcome was the evaluation of baseline daptomycin trough levels in patients undergoing TDM, and how subsequent levels were affected by potential

SUBMITTER: Hellwege RS 

PROVIDER: S-EPMC12932621 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature