Enhancing photothermal therapy effectiveness via tartrazine-induced optical clearing of biological tissues.

ABSTRACT: Photothermal therapies offer a powerful strategy for noninvasive treatment of cancer and other pathological conditions by converting light energy into localized heat to ablate diseased tissues or induce local release of antigens. However, the efficacy and precision of these therapies are severely restricted by optical scattering in biological tissues, which limits light penetration and spatial accuracy in vivo. In this work, we leverage the food coloring dye tartrazine-a strongly absorbing molecule in UV-VIS range ([Formula: see text]250 nm and [Formula: see text]430 nm) and with minimal absorption over 600 nm-to reduce tissue scattering and thereby enhance the delivery and efficacy of photothermal treatment. We demonstrate that when in aqueous environments, tartrazine induces local refrac

SUBMITTER: Minopoli A 

PROVIDER: S-EPMC12932669 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature