Predicting induction chemotherapy response based on tumor-stroma ratio and pretreatment synthetic MRI in nasopharyngeal carcinoma.

ABSTRACT:

Objective

There is no satisfactory model for predicting the therapeutic response to chemotherapy of nasopharyngeal carcinoma (NPC). We developed a nomogram using tumor-stroma ratio (TSR) and histogram features from pretreatment synthetic magnetic resonance MRI (SyMRI) to assess induction chemotherapy (IC) response in NPC.

Materials and methods

Data from 185 NPC patients were retrospectively collected from July 2022 to November 2023 (training cohort), and 82 NPC patients were prospectively enrolled from December 2023 to July 2024 (test cohort). A nomogram was developed to predict IC response using logistic regression based on clinicopathological and imaging features from SyMRI T1-, T2-, and proton density (PD)-weighted images, and apparent diffusion coefficient (ADC) maps. Th

SUBMITTER: Ren H 

PROVIDER: S-EPMC12932746 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature